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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346279
Species: Homo sapiens
RGD Object: Gene
Symbol: TCIM
Name: transcriptional and immune response regulator
Acc ID: CHEBI:72564
Term: temozolomide
Definition: An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.
Chemical ID: MESH:C047246
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TCIMincreases expressionEXP 6480464CTDTemozolomide results in increased expression of TCIM mRNAPMID:31758290
TCIMincreases response to substanceEXP 6480464CTDTCIM mRNA results in increased susceptibility to temozolomidePMID:16365179
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