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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558619
Species: Mus musculus
RGD Object: Gene
Symbol: Ctsb
Name: cathepsin B
Acc ID: CHEBI:71952
Term: dactolisib
Definition: An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment.
Chemical ID: MESH:C531198
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctsbaffects localizationISOCTSB (Homo sapiens)6480464CTDdactolisib affects the localization of CTSB proteinPMID:23151917
Ctsbmultiple interactionsISOCTSB (Homo sapiens)6480464CTD[Chloroquine co-treated with dactolisib] affects the localization of CTSB proteinPMID:23151917
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