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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620248
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb4
Name: ATP binding cassette subfamily B member 4
Acc ID: CHEBI:71416
Term: phenazopyridine
Definition: A diaminopyridine that is 2,6-diaminopyridine substituted at position 3 by a phenylazo group. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.
Chemical ID: MESH:D010621
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb4decreases activityISORGD:7369466480464CTDPhenazopyridine results in decreased activity of ABCB4 protein

PMID:28437613
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