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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:71415
Term: nitrofurantoin
Definition: An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.
Chemical ID: MESH:D009582
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityEXP 6480464CTDNitrofurantoin results in decreased activity of GSR proteinPMID:1313237
Gsrdecreases activityISOGsr (Mus musculus)6480464CTDNitrofurantoin results in decreased activity of GSR proteinPMID:9000262
Gsrmultiple interactionsISOGSR (Homo sapiens)6480464CTD[Nitrofurantoin co-treated with GSR protein] affects the metabolism of GlucosePMID:1901343
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