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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:71219
Term: pazopanib
Definition: A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.
Chemical ID: MESH:C516667
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3decreases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDpazopanib results in decreased phosphorylation of MAPK3 proteinPMID:27560553
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTDmirdametinib promotes the reaction [pazopanib results in decreased phosphorylation of MAPK3 protein]PMID:27560553
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