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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3931
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ucp1
Name: uncoupling protein 1
Acc ID: CHEBI:71200
Term: tofacitinib
Definition: A pyrrolopyrimidine that is pyrrolo[2,3-d]pyrimidine substituted at position 4 by an N-methyl,N-(1-cyanoacetyl-4-methylpiperidin-3-yl)amino moiety. Used as its citrate salt to treat moderately to severely active rheumatoid arthritis.
Chemical ID: MESH:C479163
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ucp1increases expressionISOUCP1 (Homo sapiens)6480464CTDtofacitinib results in increased expression of UCP1 mRNA; tofacitinib results in increased expression of UCP1 proteinPMID:25487280
Ucp1multiple interactionsISOUCP1 (Homo sapiens)6480464CTDcyclopamine inhibits the reaction [tofacitinib results in increased expression of UCP1 mRNA]; tofacitinib inhibits the reaction [TNF protein results in decreased expression of UCP1 mRNA]PMID:25487280
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