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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2110
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ampd2
Name: adenosine monophosphate deaminase 2
Acc ID: CHEBI:71200
Term: tofacitinib
Definition: A pyrrolopyrimidine that is pyrrolo[2,3-d]pyrimidine substituted at position 4 by an N-methyl,N-(1-cyanoacetyl-4-methylpiperidin-3-yl)amino moiety. Used as its citrate salt to treat moderately to severely active rheumatoid arthritis.
Chemical ID: MESH:C479163
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ampd2decreases expressionISOAMPD2 (Homo sapiens)6480464CTDtofacitinib results in decreased expression of AMPD2 proteinPMID:25496463
Ampd2multiple interactionsISOAMPD2 (Homo sapiens)6480464CTD[tofacitinib results in decreased expression of AMPD2 protein] which affects the abundance of AdenosinePMID:25496463
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