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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:71045
Term: bisdemethoxycurcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups.
Chemical ID: MESH:C034786
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDbis(4-hydroxycinnamoyl)methane results in increased expression of NQO1 mRNA, bis(4-hydroxycinnamoyl)methane results in increased expression of NQO1 protein

PMID:19188863
increases expressionISORGD:104736480464CTDbis(4-hydroxycinnamoyl)methane results in increased expression of NQO1 mRNA

PMID:17535857
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.