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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619570
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK3
Name: mitogen-activated protein kinase 3
Acc ID: CHEBI:71045
Term: bisdemethoxycurcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups.
Chemical ID: MESH:C034786
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK3decreases expressionEXP 6480464CTDbisdemethoxycurcumin results in decreased expression of MAPK3 protein modified formPMID:35735092
MAPK3multiple interactionsEXP 6480464CTD[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; bisdemethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]PMID:35752269
MAPK3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDbisdemethoxycurcumin results in increased phosphorylation of MAPK3 proteinPMID:17535857
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