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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733440
Species: Homo sapiens
RGD Object: Gene
Symbol: BECN1
Name: beclin 1
Acc ID: CHEBI:71028
Term: carglumic acid
Definition: A urea that is the N-carbamoyl derivative of L-glutamic acid. An orphan drug used to treat a deficiency in the enzyme N-acetylglutamate synthase, which leads to acute hyperammonaemia.
Chemical ID: MESH:C006895
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BECN1multiple interactionsISOBecn1 (Mus musculus)6480464CTDN-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of BECN1 mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of BECN1 protein]PMID:31369747
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