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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732685
Species: Mus musculus
RGD Object: Gene
Symbol: Acox1
Name: acyl-Coenzyme A oxidase 1, palmitoyl
Acc ID: CHEBI:70778
Term: GW 7647
Definition: A monocarboxylic acid that is 2-(phenylsulfanyl)isobutyric acid in which the phenyl group is substituted at the para- position by a 3-aza-7-cyclohexylhept-1-yl group in which the nitrogen is acylated by a (cyclohexylamino)carbonyl group.
Chemical ID: MESH:C453899
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acox1increases expressionEXP 6480464CTDGW 7647 results in increased expression of ACOX1 mRNAPMID:21324916 PMID:23014847 PMID:34081128
Acox1multiple interactionsEXP 6480464CTDGW 6471 inhibits the reaction [GW 7647 results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [GW 7647 results in increased expression of ACOX1 mRNA]; PPARA protein promotes the reaction [GW 7647 results in increased expression of ACOX1 mRNA]PMID:21324916 PMID:34081128
Acox1increases expressionISOACOX1 (Homo sapiens)6480464CTDGW 7647 results in increased expression of ACOX1 mRNAPMID:30611723 PMID:31437187
Acox1multiple interactionsISOACOX1 (Homo sapiens)6480464CTD[GW 7647 co-treated with Oleic Acid] results in increased expression of ACOX1 mRNAPMID:30611723
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