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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737416
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2C19
Name: cytochrome P450 family 2 subfamily C member 19
Acc ID: CHEBI:7071
Term: N,N-diethyl-m-toluamide
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of m-toluic acid with the nitrogen of diethylamine. First developed by the U.S. Army in 1946 for use by military personnel in insect-infested areas, it is the most widely used insect repellent worldwide.
Chemical ID: MESH:D003671
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2C19increases metabolic processingEXP 6480464CTDCYP2C19 protein results in increased metabolism of DEETPMID:11854147
CYP2C19multiple interactionsEXP 6480464CTD[fipronil co-treated with DEET] results in decreased expression of CYP2C19 mRNAPMID:27091632
CYP2C19multiple interactionsISOCyp2c6 (Rattus norvegicus)6480464CTD[Permethrin co-treated with DEET] results in increased methylation of CYP2C6V1 genePMID:33148267
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