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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:7005
Term: morusin
Definition: An extended flavonoid that is flavone substituted by hydroxy groups at positions 5, 2' and 4', a prenyl group at position 3 and a 2,2-dimethyl pyran group across positions 7 and 8.
Chemical ID: MESH:C057451
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Reladecreases phosphorylationISORELA (Homo sapiens)6480464CTDmorusin results in decreased phosphorylation of RELA proteinPMID:25476160 PMID:33035517
Relamultiple interactionsISORELA (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in decreased phosphorylation of RELA protein]; morusin results in decreased phosphorylation of and affects the localization of RELA proteinPMID:25476160 PMID:33035517
Relamultiple interactionsISORela (Mus musculus)6480464CTDmorusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]PMID:28108223
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