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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735373
Species: Homo sapiens
RGD Object: Gene
Symbol: BMPR2
Name: bone morphogenetic protein receptor type 2
Acc ID: CHEBI:6980
Term: monocrotaline
Definition: A pyrrolizidine alkaloid that has formula C16H23NO6.
Chemical ID: MESH:D016686
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BMPR2decreases expressionISOBmpr2 (Rattus norvegicus)6480464CTDMonocrotaline results in decreased expression of BMPR2 mRNA; Monocrotaline results in decreased expression of BMPR2 proteinPMID:20522807 PMID:21619414 PMID:25460361
BMPR2multiple interactionsISOBmpr2 (Rattus norvegicus)6480464CTDFluoxetine inhibits the reaction [Monocrotaline results in decreased expression of BMPR2 mRNA]PMID:21619414
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