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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732909
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:6980
Term: monocrotaline
Definition: A pyrrolizidine alkaloid that has formula C16H23NO6.
Chemical ID: MESH:D016686
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT1decreases phosphorylationISOAkt1 (Rattus norvegicus)6480464CTDMonocrotaline results in decreased phosphorylation of AKT1 proteinPMID:18801959
AKT1increases phosphorylationISOAkt1 (Rattus norvegicus)6480464CTDMonocrotaline results in increased phosphorylation of AKT1 proteinPMID:30466619
AKT1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTDmagnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of AKT1 protein]; Monocrotaline affects the expression of and affects the phosphorylation of AKT1 protein; Quercetin affects the reaction [Monocrotaline affects the expression of and affects the phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Monocrotaline results in increased phosphorylation of AKT1 protein]PMID:25460361 PMID:30466619
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