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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731018
Species: Homo sapiens
RGD Object: Gene
Symbol: KDR
Name: kinase insert domain receptor
Acc ID: CHEBI:6980
Term: monocrotaline
Definition: A pyrrolizidine alkaloid that has formula C16H23NO6.
Chemical ID: MESH:D016686
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KDRdecreases expressionISOKdr (Mus musculus)6480464CTDMonocrotaline results in decreased expression of KDR mRNAPMID:33122006
KDRmultiple interactionsISOKdr (Mus musculus)6480464CTDromiplostim inhibits the reaction [Monocrotaline results in decreased expression of KDR mRNA]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of KDR mRNA]PMID:33122006
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