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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61960
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Txnrd2
Name: thioredoxin reductase 2
Acc ID: CHEBI:6980
Term: monocrotaline
Definition: A pyrrolizidine alkaloid that has formula C16H23NO6.
Chemical ID: MESH:D016686
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Txnrd2decreases expressionEXP 6480464CTDMonocrotaline results in decreased expression of TXNRD2 mRNA; Monocrotaline results in decreased expression of TXNRD2 proteinPMID:29908794
Txnrd2multiple interactionsEXP 6480464CTDliquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein]PMID:29908794
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