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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735652
Species: Homo sapiens
RGD Object: Gene
Symbol: AR
Name: androgen receptor
Acc ID: CHEBI:6954
Term: Mitotane
Definition: null
Chemical ID: MESH:D008939
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ARaffects bindingEXP 6480464CTDMitotane binds to AR proteinPMID:14579009
ARmultiple interactionsEXP 6480464CTDMitotane binds to and results in decreased activity of AR protein; Mitotane inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Mitotane inhibits the reaction [Dihydrotestosterone binds to AR protein]PMID:14579009 PMID:33049310 PMID:9705896
ARaffects bindingISOAr (Rattus norvegicus)6480464CTDMitotane binds to AR proteinPMID:14565775
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