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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347343
Species: Homo sapiens
RGD Object: Gene
Symbol: TNFSF11
Name: TNF superfamily member 11
Acc ID: CHEBI:69533
Term: rubiadin
Definition: A dihydroxyanthraquinone that is anthracene-9,10-dione substituted by hydroxy groups at positions 1 and 3 and a methyl group at position 2. It has been isolated from Rubia yunnanensis.
Chemical ID: MESH:C072500
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFSF11decreases expressionISOTnfsf11 (Rattus norvegicus)6480464CTDrubiadin results in decreased expression of TNFSF11 mRNA; rubiadin results in decreased expression of TNFSF11 proteinPMID:21945525
TNFSF11multiple interactionsISOTnfsf11 (Rattus norvegicus)6480464CTDrubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]PMID:21945525
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