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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69096
Species: Mus musculus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:6950
Term: mirtazapine
Definition: A tetracyclic antidepressant that has formula C17H19N3.
Chemical ID: MESH:C035133
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1increases expressionEXP 6480464CTDMirtazapine results in increased expression of TGFB1 mRNAPMID:35066094
Tgfb1multiple interactionsEXP 6480464CTDEthanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]; Mirtazapine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]PMID:28623179 PMID:35066094
Tgfb1increases expressionISOTgfb1 (Rattus norvegicus)6480464CTDMirtazapine results in increased expression of TGFB1 mRNAPMID:35066094
Tgfb1multiple interactionsISOTgfb1 (Rattus norvegicus)6480464CTDEthanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]PMID:35066094
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