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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737487
Species: Homo sapiens
RGD Object: Gene
Symbol: IFNG
Name: interferon gamma
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IFNGmultiple interactionsEXP 6480464CTD[Cannabidiol co-treated with TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA; [Dronabinol co-treated with Cannabidiol] inhibits the reaction [IFNG protein results in increased expression of PSMB8 mRNA]; [Dronabinol co-treated with Cannabidiol] inhibits the reaction [IFNG protein results in increased expression of PSMB8 protein]; Cannabidiol affects the reaction [Plant Preparations results in increased secretion of IFNG protein]; Cannabidiol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of TRPV1 mRNA]; Cannabidiol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA]; Cannabidiol inhibits the reaction [IFNG protein results in increased expression of PSMB8 mRNA]; Cannabidiol inhibits the reaction [IFNG protein results in increased expression of PSMB8 protein]; Cannabidiol inhibits the reaction [Plant Preparations results in increased expression of IFNG mRNA]; Cannabidiol promotes the reaction [Dronabinol inhibits the reaction [IFNG protein results in increased expression of PSMB8 mRNA]]; Dronabinol promotes the reaction [Cannabidiol inhibits the reaction [IFNG results in increased expression of PSMB8 mRNA]]PMID:19167098 PMID:27769052 PMID:31054246
IFNGmultiple interactionsISOIfng (Mus musculus)6480464CTDCannabidiol inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) results in increased susceptibility to myelin oligodendrocyte glycoprotein (35-55)] which results in increased expression of and results in increased secretion of IFNG protein]PMID:30123217
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