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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735336
Species: Mus musculus
RGD Object: Gene
Symbol: Akt1
Name: thymoma viral proto-oncogene 1
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1increases expressionEXP 6480464CTDCannabidiol results in increased expression of AKT1 mRNAPMID:33019509
Akt1affects expressionISOAKT1 (Homo sapiens)6480464CTDCannabidiol affects the expression of AKT1 proteinPMID:26504004
Akt1decreases expressionISOAKT1 (Homo sapiens)6480464CTDCannabidiol results in decreased expression of AKT1 mRNAPMID:30713602
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDCannabidiol results in decreased phosphorylation of AKT1 proteinPMID:28392768 PMID:32060308 PMID:36810933
Akt1increases expressionISOAKT1 (Homo sapiens)6480464CTDCannabidiol results in increased expression of AKT1 mRNAPMID:27932991 PMID:28025562 PMID:31801206
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDCannabidiol results in increased phosphorylation of AKT1 proteinPMID:33817834
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cannabidiol results in decreased phosphorylation of AKT1 protein]; [Cannabidiol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of AKT1 mRNA; Acetylcysteine inhibits the reaction [Cannabidiol results in decreased phosphorylation of AKT1 protein]; AM 251 inhibits the reaction [Cannabidiol results in increased phosphorylation of AKT1 protein]; Cannabidiol promotes the reaction [SB 203580 results in decreased phosphorylation of AKT1 protein]; Cannabidiol results in decreased phosphorylation of and results in decreased expression of AKT1 protein modified form; Chloroquine affects the reaction [Cannabidiol results in decreased phosphorylation of AKT1 protein]; LAIR1 protein affects the reaction [Cannabidiol results in decreased phosphorylation of AKT1 protein]; tanespimycin affects the reaction [Cannabidiol affects the expression of AKT1 protein]; VER 155008 affects the reaction [Cannabidiol affects the expression of AKT1 protein]PMID:26504004 PMID:32060308 PMID:32992648 PMID:33817834 PMID:34575494 PMID:36810933
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