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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733100
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2
Name: BCL2 apoptosis regulator
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2decreases expressionEXP 6480464CTDCannabidiol results in decreased expression of BCL2 mRNA; Cannabidiol results in decreased expression of BCL2 proteinPMID:31349651 PMID:33244087 PMID:34575494 PMID:36810933
BCL2increases expressionEXP 6480464CTDCannabidiol results in increased expression of BCL2 proteinPMID:27932991
BCL2multiple interactionsEXP 6480464CTDCannabidiol inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of BCL2 mRNA]; Cannabidiol inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of BCL2 protein]PMID:36988283
BCL2multiple interactionsISOBcl2 (Mus musculus)6480464CTDCannabidiol inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of BCL2 mRNA]; Cannabidiol inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of BCL2 protein]PMID:36988283
BCL2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTDCannabidiol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]PMID:27430346
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