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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732177
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcr4
Name: C-X-C motif chemokine receptor 4
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcr4increases expressionEXP 6480464CTDCannabidiol results in increased expression of CXCR4 mRNAPMID:30742662
Cxcr4multiple interactionsEXP 6480464CTD[lipopolysaccharide, E coli O55-B5 co-treated with Cannabidiol] results in increased expression of CXCR4 mRNAPMID:30742662
Cxcr4multiple interactionsISOCXCR4 (Homo sapiens)6480464CTD[Dronabinol co-treated with Cannabidiol] results in decreased expression of CXCR4 mRNA; carfilzomib promotes the reaction [[Dronabinol co-treated with Cannabidiol] results in decreased expression of CXCR4 mRNA]PMID:27769052
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