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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69287
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1decreases expressionISOSQSTM1 (Homo sapiens)6480464CTDCannabidiol results in decreased expression of SQSTM1 mRNA; Cannabidiol results in decreased expression of SQSTM1 proteinPMID:27769052 PMID:31801206
Sqstm1increases expressionISOSQSTM1 (Homo sapiens)6480464CTDCannabidiol results in increased expression of SQSTM1 mRNA; Cannabidiol results in increased expression of SQSTM1 proteinPMID:31518892 PMID:34302491
Sqstm1increases expressionISOSqstm1 (Mus musculus)6480464CTDCannabidiol results in increased expression of SQSTM1 mRNAPMID:21542829
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTD[Dronabinol co-treated with Cannabidiol] results in decreased expression of SQSTM1 protein; Camptothecin inhibits the reaction [Cannabidiol results in increased expression of SQSTM1 mRNA]; Dronabinol promotes the reaction [Cannabidiol results in decreased expression of SQSTM1 protein]PMID:27769052 PMID:34302491
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