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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69169
Species: Mus musculus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargaffects bindingEXP 6480464CTDCannabidiol binds to PPARG proteinPMID:19285060
Ppargincreases activityEXP 6480464CTDCannabidiol analog results in increased activity of PPARG proteinPMID:30033591
Ppargincreases expressionEXP 6480464CTDCannabidiol analog results in increased expression of PPARG mRNA alternative formPMID:30382123
Ppargmultiple interactionsEXP 6480464CTD[lipopolysaccharide, E coli O55-B5 co-treated with Cannabidiol] results in decreased expression of PPARG mRNA; Cannabidiol analog inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein]; T 0070907 inhibits the reaction [Cannabidiol analog results in increased expression of PPARG mRNA alternative form]PMID:30033591 PMID:30382123 PMID:30742662
Ppargaffects bindingISOPPARG (Homo sapiens)6480464CTDCannabidiol analog binds to PPARG proteinPMID:30033591
Ppargdecreases expressionISOPPARG (Homo sapiens)6480464CTDCannabidiol results in decreased expression of PPARG proteinPMID:28853159
Ppargincreases expressionISOPparg (Rattus norvegicus)6480464CTDCannabidiol results in increased expression of PPARG mRNAPMID:19285060
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDCannabidiol results in increased expression of PPARG mRNAPMID:23220503
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDCannabidiol analog binds to and results in increased activity of PPARG protein; Cannabidiol inhibits the reaction [Lipopolysaccharides promotes the reaction [PPARG protein binds to CMPK2 promoter]]; Cannabidiol inhibits the reaction [Lipopolysaccharides promotes the reaction [PPARG protein results in increased expression of CMPK2 mRNA]]; Cannabidiol results in increased expression of and affects the localization of PPARG protein; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Cannabidiol affects the localization of PPARG protein]PMID:23220503 PMID:30007266 PMID:30382123 PMID:34269108
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