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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620175
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgf21
Name: fibroblast growth factor 21
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgf21increases expressionISOFgf21 (Mus musculus)6480464CTDCannabidiol analog results in increased expression of FGF21 mRNAPMID:30382123
Fgf21multiple interactionsISOFgf21 (Mus musculus)6480464CTDCannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of FGF21 protein]; Cannabidiol analog inhibits the reaction [Dietary Fats results in increased expression of FGF21 mRNA]PMID:30382123 PMID:30825431
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