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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551095
Species: Mus musculus
RGD Object: Gene
Symbol: Rela
Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsEXP 6480464CTD[lipopolysaccharide, E coli O55-B5 co-treated with Cannabidiol] results in increased expression of RELA mRNA; Cannabidiol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]PMID:19910459 PMID:30742662
Reladecreases expressionISORELA (Homo sapiens)6480464CTDCannabidiol results in decreased expression of RELA mRNAPMID:27932991
Reladecreases phosphorylationISORELA (Homo sapiens)6480464CTDCannabidiol results in decreased phosphorylation of RELA proteinPMID:32060308
Relaincreases localizationISORELA (Homo sapiens)6480464CTDCannabidiol results in increased localization of RELA proteinPMID:33864076
Relamultiple interactionsISORELA (Homo sapiens)6480464CTD[Cannabidiol co-treated with 3-(4-methylphenylsulfonyl)-2-propenenitrile] results in decreased phosphorylation of RELA protein; [Cannabidiol co-treated with 4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of RELA protein; [Cannabidiol co-treated with moringin] results in increased expression of RELA mRNA; [Chloroquine co-treated with Cannabidiol] results in decreased phosphorylation of RELA protein; Cannabidiol promotes the reaction [RELA protein binds to RELA promoter]; SN50 peptide inhibits the reaction [Cannabidiol results in increased localization of RELA protein]PMID:30096889 PMID:32060308 PMID:33864076
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