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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10996
Species: Mus musculus
RGD Object: Gene
Symbol: Nos2
Name: nitric oxide synthase 2, inducible
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos2increases expressionEXP 6480464CTDCannabidiol results in increased expression of NOS2 mRNAPMID:30742662
Nos2multiple interactionsEXP 6480464CTDCannabidiol inhibits the reaction [DMD gene mutant form results in increased expression of NOS2 mRNA]; Cannabidiol inhibits the reaction [Haloperidol results in increased expression of NOS2 mRNA]PMID:30074247 PMID:30217539
Nos2multiple interactionsISONos2 (Rattus norvegicus)6480464CTDCannabidiol inhibits the reaction [Hydrogen Peroxide results in increased expression of NOS2 protein]PMID:27430346
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