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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a9
Name: cytochrome P450, family 3, subfamily a, polypeptide 9
Acc ID: CHEBI:6931
Term: midazolam
Definition: An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Chemical ID: MESH:D008874
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a9affects metabolic processingEXP 6480464CTDCYP3A5 protein affects the metabolism of MidazolamPMID:15801540
Cyp3a9affects metabolic processingISOCYP3A5 (Homo sapiens)6480464CTDCYP3A5 gene polymorphism affects the metabolism of Midazolam; CYP3A5 protein affects the metabolism of MidazolamPMID:15801540 PMID:15900284 PMID:19557931
Cyp3a9increases hydroxylationISOCYP3A5 (Homo sapiens)6480464CTDCYP3A5 protein results in increased hydroxylation of MidazolamPMID:15383492 PMID:15499178 PMID:34189909
Cyp3a9increases metabolic processingISOCYP3A5 (Homo sapiens)6480464CTDCYP3A5 protein results in increased metabolism of MidazolamPMID:26958860
Cyp3a9multiple interactionsISOCYP3A5 (Homo sapiens)6480464CTD[CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; erdafitinib inhibits the reaction [[CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; erdafitinib inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Midazolam]; fructus schizandrae, radix ginseng, radix ophiopogonis drug combination affects the reaction [CYP3A5 protein affects the metabolism of Midazolam]PMID:19557931 PMID:34189909
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