Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	619788
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Trpc6
Name:	transient receptor potential cation channel, subfamily C, member 6

Acc ID:	CHEBI:69251
Term:	(+)-conocarpan
Definition:	A member of the class of benzofurans that is 2,3-dihydro-1-benzofuran substituted by a methyl group at position 3, a prop-1-en-1-yl group at position 5 and a 4-hydroxyphenyl group at position 2. It is a lignan derivative isolated from the roots of Krameria lappacea.
Chemical ID:	MESH:C447284

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Trpc6	increases activity	ISO	RGD:732721	6480464	CTD	conocarpan results in increased activity of TRPC6 protein	PMID:31054997
Trpc6	multiple interactions	ISO	RGD:732721	6480464	CTD	SAR7334 inhibits the reaction [conocarpan results in increased activity of TRPC6 protein]	PMID:31054997

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