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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2984
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Krt8
Name: keratin 8
Acc ID: CHEBI:6925
Term: microcystin-LR
Definition: A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins.
Chemical ID: MESH:C057862
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7355376480464CTDcyanoginosin LR results in increased expression of KRT8 mRNA

PMID:17654400
multiple interactionsISORGD:7355366480464CTDcyanoginosin LR results in increased phosphorylation of and affects the expression of KRT8 protein, SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of KRT8 protein], U 0126 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of KRT8 protein]

PMID:22960429
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.