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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552027
Species: Mus musculus
RGD Object: Gene
Symbol: Ep300
Name: E1A binding protein p300
Acc ID: CHEBI:6923
Term: miconazole
Definition: A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.
Chemical ID: MESH:D008825
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ep300decreases expressionEXP 6480464CTDMiconazole results in decreased expression of EP300 mRNAPMID:27462272
Ep300decreases expressionISOEp300 (Rattus norvegicus)6480464CTDMiconazole results in decreased expression of EP300 mRNAPMID:22262564
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