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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344163
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1I3
Name: nuclear receptor subfamily 1 group I member 3
Acc ID: CHEBI:6923
Term: miconazole
Definition: A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.
Chemical ID: MESH:D008825
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1I3decreases expressionEXP 6480464CTDMiconazole results in decreased expression of NR1I3 mRNAPMID:16608920
NR1I3increases activityISONr1i3 (Rattus norvegicus)6480464CTDMiconazole results in increased activity of NR1I3 proteinPMID:27732639
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