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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:69120
Term: withaferin A
Definition: A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Physalis longifolia, it exhibits cytotoxic activity.
Chemical ID: MESH:C009684
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISORGD:691656480464CTDDDIT3 mRNA affects the susceptibility to withaferin A

PMID:21266191
increases expressionISORGD:691656480464CTDwithaferin A results in increased expression of DDIT3 protein

PMID:21266191
multiple interactionsISORGD:691656480464CTDAcetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT3 protein]

PMID:21266191
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.