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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:69082
Term: licoricidin
Definition: A member of the class of hydroxyisoflavans that is R-isoflavan with hydroxy groups at positions 7, 2' and 4', a methoxy group at position 5 and prenyl groups at positions 6 and 3'. Isolated from Glycyrrhiza uralensis, it exhibits antibacterial activity.
Chemical ID: MESH:C401293
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Reladecreases phosphorylationISORGD:13527616480464CTDlicoricidin results in decreased phosphorylation of RELA proteinPMID:29782821
Relamultiple interactionsISORGD:13527616480464CTDlicoricidin inhibits the reaction [gemcitabine results in increased phosphorylation of RELA protein]PMID:29782821
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