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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735878
Species: Homo sapiens
RGD Object: Gene
Symbol: ACHE
Name: acetylcholinesterase (Yt blood group)
Acc ID: CHEBI:6908
Term: trichlorfon
Definition: A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.
Chemical ID: MESH:D014236
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACHEdecreases activityEXP 6480464CTDTrichlorfon metabolite results in decreased activity of ACHE protein; Trichlorfon results in decreased activity of ACHE proteinPMID:10718203 PMID:10791297 PMID:11526466 PMID:15386949 PMID:15569517 PMID:18070496 PMID:1852719 PMID:18804659 PMID:19631781 PMID:30625376 PMID:4859365 PMID:8783813 PMID:9268605 PMID:9515941
ACHEmultiple interactionsEXP 6480464CTD[Trichlorfon co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]PMID:18070496 PMID:4859365 PMID:8783813
ACHEaffects activityISOAche (Rattus norvegicus)6480464CTDTrichlorfon affects the activity of ACHE proteinPMID:12111444
ACHEdecreases activityISOAche (Rattus norvegicus)6480464CTDTrichlorfon results in decreased activity of ACHE proteinPMID:11311445 PMID:11822883 PMID:235931
ACHEdecreases activityISOAche (Mus musculus)6480464CTDTrichlorfon results in decreased activity of ACHE proteinPMID:12794734 PMID:16822217 PMID:9268605 PMID:9515941
ACHEmultiple interactionsISOAche (Mus musculus)6480464CTD[Trichlorfon results in decreased activity of ACHE protein] which affects the localization of CHRM2 proteinPMID:12794734
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