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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732175
Species: Mus musculus
RGD Object: Gene
Symbol: Bche
Name: butyrylcholinesterase
Acc ID: CHEBI:6908
Term: trichlorfon
Definition: A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.
Chemical ID: MESH:D014236
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bchedecreases activityISOBche (Rattus norvegicus)6480464CTDTrichlorfon results in decreased activity of BCHE proteinPMID:11311445 PMID:235931
Bchedecreases activityISOBCHE (Homo sapiens)6480464CTDTrichlorfon results in decreased activity of BCHE proteinPMID:18825528 PMID:235931
Bchemultiple interactionsISOBCHE (Homo sapiens)6480464CTD1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; asoxime chloride inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; Obidoxime Chloride inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]PMID:18825528
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