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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733595
Species: Homo sapiens
RGD Object: Gene
Symbol: ADRB2
Name: adrenoceptor beta 2
Acc ID: CHEBI:6904
Term: metoprolol
Definition: A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Chemical ID: MESH:D008790
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ADRB2affects response to substanceEXP 6480464CTDADRB2 gene polymorphism affects the susceptibility to MetoprololPMID:17671401
ADRB2multiple interactionsEXP 6480464CTD[Metoprolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; [Metoprolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Metoprolol binds to and results in decreased activity of ADRB2 protein; Metoprolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]PMID:14730417 PMID:17925438
ADRB2affects bindingISOAdrb2 (Rattus norvegicus)6480464CTDMetoprolol binds to ADRB2 proteinPMID:9593075
ADRB2increases expressionISOAdrb2 (Mus musculus)6480464CTDMetoprolol results in increased expression of ADRB2 mRNAPMID:20675662
ADRB2increases expressionISOAdrb2 (Rattus norvegicus)6480464CTDMetoprolol results in increased expression of ADRB2 proteinPMID:18703049
ADRB2multiple interactionsISOAdrb2 (Rattus norvegicus)6480464CTDMetoprolol promotes the reaction [Streptozocin results in increased expression of ADRB2 protein]PMID:18703049
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