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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730951
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS2
Name: nitric oxide synthase 2
Acc ID: CHEBI:6872
Term: methylene blue
Definition: An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties.
Chemical ID: MESH:D008751
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS2multiple interactionsISONos2 (Mus musculus)6480464CTDMethylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]PMID:24556215
NOS2multiple interactionsISONos2 (Rattus norvegicus)6480464CTDMethylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]PMID:31428839
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