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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2980
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kng2
Name: kininogen 2
Acc ID: CHEBI:68556
Term: icatibant
Definition: A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acute attacks of hereditary angioedema in adult patients.
Chemical ID: MESH:C065679
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kng2decreases activityEXP 6480464CTDicatibant results in decreased activity of KNG1PMID:1334751
Kng2multiple interactionsEXP 6480464CTDicatibant inhibits the reaction [[KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein] which results in increased abundance of Inositol Phosphates]; icatibant inhibits the reaction [KNG1 protein inhibits the reaction [Potassium Chloride results in increased secretion of TAC1 protein]]; icatibant inhibits the reaction [KNG1 results in increased expression of PTGS2 mRNA]; icatibant inhibits the reaction [KNG1 results in increased secretion of TAC1 protein]PMID:15750287 PMID:16696851 PMID:17347322 PMID:22198006
Kng2multiple interactionsISORGD:16037136480464CTDicatibant inhibits the reaction [KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein]PMID:15140628
Kng2multiple interactionsISORGD:16171856480464CTDicatibant inhibits the reaction [KNG1 protein modified form binds to BDKRB2 protein]PMID:30685357
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