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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344163
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1I3
Name: nuclear receptor subfamily 1 group I member 3
Acc ID: CHEBI:68540
Term: teriflunomide
Definition: An enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. Used for the treatment of relapsing forms of multiple sclerosis and rheumatoid arthritis.
Chemical ID: MESH:C072876
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1I3affects localizationEXP 6480464CTDteriflunomide affects the localization of NR1I3 protein mutant formPMID:30364229
NR1I3increases expressionEXP 6480464CTDteriflunomide results in increased expression of NR1I3 mRNAPMID:30364229
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