GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | affects localization | EXP | | 6480464 | CTD | diethyl maleate affects the localization of NFE2L2 protein | PMID:12235164 | Nfe2l2 | decreases response to substance | EXP | | 6480464 | CTD | NFE2L2 results in decreased susceptibility to diethyl maleate | PMID:12235164 | Nfe2l2 | increases activity | EXP | | 6480464 | CTD | diethyl maleate results in increased activity of NFE2L2 protein | PMID:30114225 | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA] | PMID:12235164 PMID:22003191 | Nfe2l2 | affects localization | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | diethyl maleate affects the localization of NFE2L2 protein | PMID:27982581 | Nfe2l2 | increases expression | ISO | Nfe2l2 (Rattus norvegicus) | 6480464 | CTD | diethyl maleate results in increased expression of NFE2L2 protein | PMID:21465251 | Nfe2l2 | increases expression | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | diethyl maleate results in increased expression of NFE2L2 protein | PMID:27358234 | Nfe2l2 | multiple interactions | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | [diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein; diethyl maleate binds to and results in increased activity of NFE2L2 protein; diethyl maleate promotes the reaction [NFE2L2 protein binds to SMPD1 promoter]; diethyl maleate results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; NFE2L2 protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate results in increased expression of NFE2L2 protein]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein] | PMID:20806931 PMID:25762726 PMID:27982581 PMID:34021431 PMID:35724838 | |
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