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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734432
Species: Mus musculus
RGD Object: Gene
Symbol: Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Acc ID: CHEBI:68508
Term: diethyl maleate
Definition: A maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. A colourless liquid at room temperature (m.p. -10degreeC) with boiling point 220degreeC at 1 atm., it is commonly used as a dienophile for Diels-Alder-type cycloaddition reactions in organic synthesis.
Chemical ID: MESH:C014476
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects localizationEXP 6480464CTDdiethyl maleate affects the localization of NFE2L2 proteinPMID:12235164
Nfe2l2decreases response to substanceEXP 6480464CTDNFE2L2 results in decreased susceptibility to diethyl maleatePMID:12235164
Nfe2l2increases activityEXP 6480464CTDdiethyl maleate results in increased activity of NFE2L2 proteinPMID:30114225
Nfe2l2multiple interactionsEXP 6480464CTDNFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]PMID:12235164 PMID:22003191
Nfe2l2affects localizationISONFE2L2 (Homo sapiens)6480464CTDdiethyl maleate affects the localization of NFE2L2 proteinPMID:27982581
Nfe2l2increases expressionISONfe2l2 (Rattus norvegicus)6480464CTDdiethyl maleate results in increased expression of NFE2L2 proteinPMID:21465251
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDdiethyl maleate results in increased expression of NFE2L2 proteinPMID:27358234
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein; diethyl maleate binds to and results in increased activity of NFE2L2 protein; diethyl maleate promotes the reaction [NFE2L2 protein binds to SMPD1 promoter]; diethyl maleate results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; NFE2L2 protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate results in increased expression of NFE2L2 protein]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]PMID:20806931 PMID:25762726 PMID:27982581 PMID:34021431 PMID:35724838
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