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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69218
Species: Mus musculus
RGD Object: Gene
Symbol: Aldh2
Name: aldehyde dehydrogenase 2, mitochondrial
Acc ID: CHEBI:68508
Term: diethyl maleate
Definition: A maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. A colourless liquid at room temperature (m.p. -10degreeC) with boiling point 220degreeC at 1 atm., it is commonly used as a dienophile for Diels-Alder-type cycloaddition reactions in organic synthesis.
Chemical ID: MESH:C014476
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh2decreases reductionEXP 6480464CTDdiethyl maleate results in decreased reduction of ALDH2 proteinPMID:19843705
Aldh2decreases expressionISOAldh2 (Rattus norvegicus)6480464CTDdiethyl maleate results in decreased expression of ALDH2 proteinPMID:21161181
Aldh2increases expressionISOAldh2 (Rattus norvegicus)6480464CTDdiethyl maleate results in increased expression of ALDH2 proteinPMID:21161181
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