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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10828
Species: Mus musculus
RGD Object: Gene
Symbol: Jun
Name: jun proto-oncogene
Acc ID: CHEBI:68508
Term: diethyl maleate
Definition: A maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. A colourless liquid at room temperature (m.p. -10degreeC) with boiling point 220degreeC at 1 atm., it is commonly used as a dienophile for Diels-Alder-type cycloaddition reactions in organic synthesis.
Chemical ID: MESH:C014476
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junincreases expressionEXP 6480464CTDdiethyl maleate results in increased expression of JUN mRNAPMID:10915739 PMID:12774022
Junincreases phosphorylationEXP 6480464CTDdiethyl maleate results in increased phosphorylation of JUN proteinPMID:12774022
Junmultiple interactionsEXP 6480464CTDpyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]PMID:12774022
Junincreases expressionISOJUN (Homo sapiens)6480464CTDdiethyl maleate results in increased expression of JUN protein modified formPMID:30261343
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of JUN protein modified form]PMID:30261343
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