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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10652
Species: Mus musculus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:68508
Term: diethyl maleate
Definition: A maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. A colourless liquid at room temperature (m.p. -10degreeC) with boiling point 220degreeC at 1 atm., it is commonly used as a dienophile for Diels-Alder-type cycloaddition reactions in organic synthesis.
Chemical ID: MESH:C014476
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcincreases activityEXP 6480464CTDdiethyl maleate results in increased activity of GCLC proteinPMID:10915739
Gclcincreases expressionEXP 6480464CTDdiethyl maleate results in increased expression of GCLC mRNA; diethyl maleate results in increased expression of GCLC proteinPMID:10915739 PMID:25270620
Gclcincreases activityISOGclc (Rattus norvegicus)6480464CTDdiethyl maleate results in increased activity of GCLC proteinPMID:15115889
Gclcincreases expressionISOGclc (Rattus norvegicus)6480464CTDdiethyl maleate results in increased expression of GCLC mRNA; diethyl maleate results in increased expression of GCLC proteinPMID:10978506 PMID:15115889 PMID:21465251
Gclcincreases expressionISOGCLC (Homo sapiens)6480464CTDdiethyl maleate results in increased expression of GCLC mRNA; diethyl maleate results in increased expression of GCLC proteinPMID:33545341 PMID:34021431 PMID:34480604
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