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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735711
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1A2
Name: cytochrome P450 family 1 subfamily A member 2
Acc ID: CHEBI:68444
Term: 1-methyl-7H-xanthine
Definition: A 1-methylxanthine tautomer where the imidazole proton is located at the 7-position.
Chemical ID: MESH:C053085
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1A2decreases activityEXP 6480464CTD1-methylxanthine results in decreased activity of CYP1A2 proteinPMID:11465391
CYP1A2multiple interactionsEXP 6480464CTD[CYP1A2 protein results in increased metabolism of 1,7-dimethylxanthine] which results in increased chemical synthesis of 1-methylxanthinePMID:19215233
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