GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | AR | affects binding | EXP | | 6480464 | CTD | Methoxychlor binds to AR protein | PMID:15253041 | AR | decreases activity | EXP | | 6480464 | CTD | Methoxychlor metabolite results in decreased activity of AR protein; Methoxychlor results in decreased activity of AR protein | PMID:11861975 PMID:26867867 | AR | multiple interactions | EXP | | 6480464 | CTD | Dihydrotestosterone inhibits the reaction [Methoxychlor results in increased activity of AR protein]; Methoxychlor affects the reaction [CGA protein results in increased expression of AR mRNA]; Methoxychlor analog binds to and results in decreased activity of AR protein; Methoxychlor binds to and results in decreased activity of AR protein; Methoxychlor inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Methoxychlor inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Methoxychlor inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Methoxychlor inhibits the reaction [Metribolone results in increased activity of AR protein]; Methoxychlor inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]; Methoxychlor inhibits the reaction [Stanozolol results in increased activity of AR protein]; Methoxychlor metabolite binds to and results in decreased activity of AR protein; Methoxychlor metabolite inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Methoxychlor metabolite inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Methoxychlor metabolite inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] | PMID:10999957 PMID:11861976 PMID:15064155 PMID:15483189 PMID:15589981 PMID:16111029 PMID:18324785 PMID:27391359 PMID:28009930 PMID:28377212 PMID:29162470 PMID:33049310 | AR | affects binding | ISO | Ar (Rattus norvegicus) | 6480464 | CTD | Methoxychlor binds to AR protein | PMID:14565775 | AR | decreases expression | ISO | Ar (Mus musculus) | 6480464 | CTD | Methoxychlor metabolite results in decreased expression of AR mRNA | PMID:11509743 | AR | decreases expression | ISO | Ar (Rattus norvegicus) | 6480464 | CTD | Methoxychlor results in decreased expression of AR mRNA | PMID:22285353 | AR | increases expression | ISO | Ar (Mus musculus) | 6480464 | CTD | Methoxychlor results in increased expression of AR mRNA | PMID:21252393 | AR | multiple interactions | ISO | Ar (Mus musculus) | 6480464 | CTD | [Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of AR mRNA; ESR1 protein promotes the reaction [Methoxychlor results in increased expression of AR mRNA] | PMID:11509743 PMID:21252393 | |
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