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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735652
Species: Homo sapiens
RGD Object: Gene
Symbol: AR
Name: androgen receptor
Acc ID: CHEBI:6842
Term: methoxychlor
Definition: An organochlorine insecticide that has formula C16H15Cl3O2.
Chemical ID: MESH:D008731
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ARaffects bindingEXP 6480464CTDMethoxychlor binds to AR proteinPMID:15253041
ARdecreases activityEXP 6480464CTDMethoxychlor metabolite results in decreased activity of AR protein; Methoxychlor results in decreased activity of AR proteinPMID:11861975 PMID:26867867
ARmultiple interactionsEXP 6480464CTDDihydrotestosterone inhibits the reaction [Methoxychlor results in increased activity of AR protein]; Methoxychlor affects the reaction [CGA protein results in increased expression of AR mRNA]; Methoxychlor analog binds to and results in decreased activity of AR protein; Methoxychlor binds to and results in decreased activity of AR protein; Methoxychlor inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Methoxychlor inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Methoxychlor inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Methoxychlor inhibits the reaction [Metribolone results in increased activity of AR protein]; Methoxychlor inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]; Methoxychlor inhibits the reaction [Stanozolol results in increased activity of AR protein]; Methoxychlor metabolite binds to and results in decreased activity of AR protein; Methoxychlor metabolite inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Methoxychlor metabolite inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Methoxychlor metabolite inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]PMID:10999957 PMID:11861976 PMID:15064155 PMID:15483189 PMID:15589981 PMID:16111029 PMID:18324785 PMID:27391359 PMID:28009930 PMID:28377212 PMID:29162470 PMID:33049310
ARaffects bindingISOAr (Rattus norvegicus)6480464CTDMethoxychlor binds to AR proteinPMID:14565775
ARdecreases expressionISOAr (Mus musculus)6480464CTDMethoxychlor metabolite results in decreased expression of AR mRNAPMID:11509743
ARdecreases expressionISOAr (Rattus norvegicus)6480464CTDMethoxychlor results in decreased expression of AR mRNAPMID:22285353
ARincreases expressionISOAr (Mus musculus)6480464CTDMethoxychlor results in increased expression of AR mRNAPMID:21252393
ARmultiple interactionsISOAr (Mus musculus)6480464CTD[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of AR mRNA; ESR1 protein promotes the reaction [Methoxychlor results in increased expression of AR mRNA]PMID:11509743 PMID:21252393
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