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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:6842
Term: methoxychlor
Definition: An organochlorine insecticide that has formula C16H15Cl3O2.
Chemical ID: MESH:D008731
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2affects methylationEXP 6480464CTDMethoxychlor affects the methylation of BCL2 genePMID:35440735
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDMethoxychlor results in decreased expression of BCL2 mRNAPMID:16081520
Bcl2decreases response to substanceISOBcl2 (Mus musculus)6480464CTDBCL2 protein results in decreased susceptibility to MethoxychlorPMID:14973267 PMID:16081520
Bcl2increases expressionISOBcl2 (Mus musculus)6480464CTDMethoxychlor metabolite results in increased expression of BCL2 protein; Methoxychlor results in increased expression of BCL2 proteinPMID:15525693
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD[ESR1 gene mutant form results in increased susceptibility to Methoxychlor] which results in increased expression of BCL2 mRNAPMID:22306526
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