GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP2C8 | decreases methylation | EXP | | 6480464 | CTD | CYP2C8 protein results in decreased methylation of Methoxychlor | PMID:12167570 PMID:12433799 | CYP2C8 | decreases activity | ISO | Cyp2c29 (Mus musculus) | 6480464 | CTD | Methoxychlor results in decreased activity of CYP2C29 protein | PMID:18420780 | CYP2C8 | increases expression | ISO | Cyp2c29 (Mus musculus) | 6480464 | CTD | Methoxychlor results in increased expression of CYP2C29 mRNA | PMID:16280380 PMID:21252393 | CYP2C8 | multiple interactions | ISO | Cyp2c29 (Mus musculus) | 6480464 | CTD | ESR1 protein promotes the reaction [Methoxychlor results in increased expression of CYP2C29 mRNA]; fulvestrant inhibits the reaction [Methoxychlor results in increased expression of CYP2C29 mRNA] | PMID:16280380 PMID:21252393 | | ||||||||||||||||||||||
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